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Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Space Sciences

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

D. Malhan, M. Yalçin, et al.

This groundbreaking research by Deeksha Malhan, Müge Yalçin, Britt Schoenrock, Dieter Blottner, and Angela Relógio uncovers how circadian clock disruptions during long-term spaceflights and aging affect skeletal muscle gene expression. The study reveals critical insights into combating musculoskeletal atrophy in astronauts by maintaining circadian function through factors like exercise and fasting.

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Playback language: English
Abstract
This research investigates the impact of circadian clock disruptions on skeletal muscle gene expression during long-term spaceflights and aging. Utilizing published omics datasets from spaceflights and Earth-based conditions (fasting, exercise, aging), the study identified alterations in the clock network and skeletal muscle pathways in mice during spaceflight, mirroring aging-related changes in humans. External factors like exercise and fasting showed potential for compensating for spaceflight-induced circadian disruption. Maintaining circadian function is crucial for mitigating musculoskeletal atrophy in astronauts.
Publisher
npj Microgravity
Published On
Apr 03, 2023
Authors
Deeksha Malhan, Müge Yalçin, Britt Schoenrock, Dieter Blottner, Angela Relógio
Tags
circadian clock
skeletal muscle
spaceflight
gene expression
aging
musculoskeletal atrophy

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