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Abstract
This study developed an injectable pig cartilage-derived decellularized extracellular matrix (dECM) hydrogel for cartilage defect repair. The dECM hydrogels enhanced the chondrogenic differentiation of human urine-derived stem cells (USCs) *in vitro* and *in vivo*. USCs within the dECM hydrogels produced cartilage-specific extracellular matrix, modulated immune response, and promoted cartilage regeneration in a rat model.
Publisher
npj Regenerative Medicine
Published On
Dec 22, 2022
Authors
Junfeng Zeng, Liping Huang, Huazhang Xiong, Qianjin Li, Chenyu Wu, Yizhou Huang, Huiqi Xie, Bin Shen
Tags
dECM hydrogel
cartilage regeneration
human urine-derived stem cells
chondrogenic differentiation
cartilage defect repair

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