This study investigated the association between nitrate and nitrite ingestion and the incidence of end-stage renal disease (ESRD) among pesticide applicators and their spouses. Water nitrate levels and total dietary nitrate/nitrite were not associated with ESRD. However, increased ESRD risk was linked to nitrate and nitrite from processed meats. Apparent associations between nitrite and ESRD were observed only in participants with below-median vitamin C intake or above-median heme iron intake. The study suggests dietary nitrite and possibly nitrate from processed meat as potential ESRD contributors.
Publisher
Journal of Exposure Science & Environmental Epidemiology
Published On
Jan 08, 2024
Authors
Dazhe Chen, Christine G. Parks, Laura E. Beane Freeman, Jonathan N. Hofmann, Rashmi Sinha, Jessica M. Madrigal, Mary H. Ward, Dale P. Sandler
Tags
nitrate
nitrite
end-stage renal disease
processed meats
dietary intake
pesticide applicators
vitamin C
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