Medicine and Health

Ingested nitrate and nitrite and end-stage renal disease in licensed pesticide applicators and spouses in the Agricultural Health Study

D. Chen, C. G. Parks, et al.

This intriguing study reveals a potential link between processed meat consumption and the risk of end-stage renal disease (ESRD) in pesticide applicators and their spouses. Conducted by a team of experts including Dazhe Chen and Christine G. Parks, the research highlights the importance of dietary choices in influencing health outcomes.

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Abstract

This study investigated the association between nitrate and nitrite ingestion and the incidence of end-stage renal disease (ESRD) among pesticide applicators and their spouses. Water nitrate levels and total dietary nitrate/nitrite were not associated with ESRD. However, increased ESRD risk was linked to nitrate and nitrite from processed meats. Apparent associations between nitrite and ESRD were observed only in participants with below-median vitamin C intake or above-median heme iron intake. The study suggests dietary nitrite and possibly nitrate from processed meat as potential ESRD contributors.

Publisher

Journal of Exposure Science & Environmental Epidemiology

Published On

Jan 08, 2024

Authors

Dazhe Chen, Christine G. Parks, Laura E. Beane Freeman, Jonathan N. Hofmann, Rashmi Sinha, Jessica M. Madrigal, Mary H. Ward, Dale P. Sandler

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