This double-blinded cluster-randomized controlled trial investigated the impact of six months of multi-micronutrient fortified rice consumption on the fecal microbiota of 380 Cambodian schoolchildren. The study characterized the association between fecal microbiota (16SrRNA sequencing), age, sex, nutritional status, micronutrient status, inflammation, and parasitic infection. Results showed a surprisingly high proportion of *Lactobacillaceae* in the fecal microbiota. Deficiencies in iron and vitamin A correlated with specific microbiota profiles, while zinc deficiency showed no association. The nutritional intervention impacted both the composition and predicted functions of the microbiota.
Publisher
Nature Communications
Published On
Jun 18, 2024
Authors
Yohannes Seyoum, Valérie Greffeuille, Dorgeles Kouakou Dje Kouadio, Khov Kuong, Williams Turpin, Rachida M'Rabt, Vincent Chochois, Sonia Fortin, Marlène Perignon, Marion Fiorentino, Jacques Berger, Kurt Burja, Maiza Campos Ponce, Chhoun Chamnan, Frank T. Wieringa, Christèle Humblot
Tags
fecal microbiota
multi-micronutrient
Cambodian schoolchildren
nutritional status
iron deficiency
vitamin A deficiency
zinc
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