This secondary analysis of the MARCH trial examined the longitudinal associations between dietary fiber intake and clinical outcomes in 551 newly diagnosed type 2 diabetes mellitus (T2DM) patients treated with metformin or acarbose for 48 weeks. Higher total and whole grain fiber intake correlated with improved β-cell function and glycemic control under acarbose. Legume fiber intake was linked to better glycemic control in both treatment groups and weight loss under metformin. A high-carbohydrate, low-fiber diet showed mixed effects, negatively impacting glycemic control and HDL-C under acarbose but positively influencing insulin sensitivity and weight loss under metformin. The study highlights the importance of considering dietary fiber sources and their interaction with oral glucose-lowering medications for optimal T2DM management.
Publisher
Nutrition and Diabetes
Published On
Oct 02, 2024
Authors
Jia Liu, Yu An, Ning Yang, Yuan Xu, Guang Wang
Tags
dietary fiber
type 2 diabetes
glycemic control
metformin
acarbose
β-cell function
weight loss
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