A pilot randomized controlled trial investigating the effects of an anti-inflammatory dietary pattern on disease activity, symptoms and microbiota profile in adults with inflammatory bowel disease

This pilot randomized controlled trial investigated the efficacy of a modified anti-inflammatory dietary pattern (IBD-MAID) designed to reduce food additives, compared to standard care, on disease activity in adults with IBD. Adults with IBD were randomized to IBD-MAID (meals provided) or general healthy eating (GHE) for 8 weeks. While no statistically significant difference was found between groups at week 8, the IBD-MAID group showed significant improvements in symptoms, quality of life, fecal calprotectin, and Crohn's disease activity. A correlation was found between reduced food additive intake and improvements in inflammatory markers and quality of life. Further research is needed to explore the effects of food additives on IBD.

Abigail Marsh, Veronique Chachay, Merrilyn Banks, Satomi Okano, Gunter Hartel, Graham Radford-Smith