Health and Fitness

Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice

Y. Seyoum, V. Greffeuille, et al.

This groundbreaking study reveals the profound effects of multi-micronutrient fortified rice on the fecal microbiota of Cambodian schoolchildren, showcasing a striking connection between nutritional deficiencies and microbiota profiles. Conducted by a team of experts, including Yohannes Seyoum and Valérie Greffeuille, this research delves into the intricate relationship between diet and gut health.

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Abstract

This double-blinded cluster-randomized controlled trial investigated the impact of six months of multi-micronutrient fortified rice consumption on the fecal microbiota of 380 Cambodian schoolchildren. The study characterized the association between fecal microbiota (16SrRNA sequencing), age, sex, nutritional status, micronutrient status, inflammation, and parasitic infection. Results showed a surprisingly high proportion of *Lactobacillaceae* in the fecal microbiota. Deficiencies in iron and vitamin A correlated with specific microbiota profiles, while zinc deficiency showed no association. The nutritional intervention impacted both the composition and predicted functions of the microbiota.

Publisher

Nature Communications

Published On

Jun 18, 2024

Authors

Yohannes Seyoum, Valérie Greffeuille, Dorgeles Kouakou Dje Kouadio, Khov Kuong, Williams Turpin, Rachida M'Rabt, Vincent Chochois, Sonia Fortin, Marlène Perignon, Marion Fiorentino, Jacques Berger, Kurt Burja, Maiza Campos Ponce, Chhoun Chamnan, Frank T. Wieringa, Christèle Humblot

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