Effects of a Combined Strength and Endurance Training Program on Gut Microbiota Composition, Functionality, and Inflammatory Status in Obese Children

This study investigated the effects of a 12-week combined strength and endurance training program on the gut microbiota composition, functionality, and inflammatory status of obese children. The results showed that the training program favorably modified the gut microbiota composition, reducing the Proteobacteria phylum and Gammaproteobacteria class, and increasing beneficial genera such as Blautia, Dialister, and Roseburia. The training also altered fecal metabolites, reducing branched-chain amino acids and sugars. Furthermore, the study observed a significant downregulation of the NLRP3 inflammasome and CASP-1 proteins, indicating an improvement in the inflammatory state. While the training increased strength in both upper and lower extremities, it didn't significantly affect anthropometric parameters.

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