Medicine and Health

Effects of ketogenic diet on the classification and functional composition of intestinal flora in children with mitochondrial epilepsy

J. Wang, L. Huang, et al.

This groundbreaking study explores how a ketogenic diet transforms the gut microbiota in children with mitochondrial epilepsy. The researchers observed significant shifts in bacterial composition, indicating potential biomarkers for the therapeutic benefits of the diet. Insights from this research were brought to light by a team of experts including Jing Wang and Lijuan Huang from Wuhan Children's Hospital.

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Abstract

This study investigated the effects of a ketogenic diet (KD) on the gut microbiota of children with mitochondrial epilepsy. Fecal samples were collected before and after a 3-month KD intervention. 16S rRNA sequencing revealed that KD reduced Firmicutes abundance and increased Bacteroidota abundance, with a significant increase in Bacteroides fragilis. Functional analysis showed differences in 12 KEGG pathways at level 3, suggesting KD alters gut microbiota composition and function. These changes may serve as biomarkers for KD's therapeutic effects.

Publisher

Frontiers in Neurology

Published On

Jul 31, 2023

Authors

Jing Wang, Lijuan Huang, Hua Li, Guohong Chen, Liming Yang, Dong Wang, Hong Han, Guo Zheng, Xu Wang, Jianmin Liang, Weijie He, Jianxiang Liao, Simone Perottoni, Dan Sun, Khojasteh Malekmohammad, Valentina Biagioli

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