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Abstract
This study investigated the effects of a ketogenic diet (KD) on the gut microbiota of children with mitochondrial epilepsy. Fecal samples were collected before and after a 3-month KD intervention. 16S rRNA sequencing revealed that KD reduced Firmicutes abundance and increased Bacteroidota abundance, with a significant increase in Bacteroides fragilis. Functional analysis showed differences in 12 KEGG pathways at level 3, suggesting KD alters gut microbiota composition and function. These changes may serve as biomarkers for KD's therapeutic effects.
Publisher
Frontiers in Neurology
Published On
Jul 31, 2023
Authors
Jing Wang, Lijuan Huang, Hua Li, Guohong Chen, Liming Yang, Dong Wang, Hong Han, Guo Zheng, Xu Wang, Jianmin Liang, Weijie He, Jianxiang Liao, Simone Perottoni, Dan Sun, Khojasteh Malekmohammad, Valentina Biagioli
Tags
ketogenic diet
gut microbiota
mitochondrial epilepsy
Bacteroidota
Firmicutes
16S rRNA sequencing
biomarkers

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