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Abstract
This paper reports the development of a compact fluorescent labeling reagent, 2-isobutenylcarbonyl-1,3a,6a-triazapentalene (TAP-VK1), derived from 1,3a,6a-triazapentalenes. TAP-VK1 reacts specifically with aliphatic thiols, exhibiting a significant increase in fluorescence intensity after thiol addition. Its utility is demonstrated through the successful fluorescence imaging of Captopril, a small molecule drug, in living cells.
Publisher
Communications Chemistry
Published On
Jan 09, 2020
Authors
Atsushi Nakayama, Akira Otani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Akira Nakayama, Kohji Itoh, Akira Otaka, Keiji Tanino, Kosuke Namba
Tags
fluorescent labeling reagent
TAP-VK1
aliphatic thiols
fluorescence imaging
Captopril
living cells
chemical sensing

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