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Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent

Chemistry

Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent

A. Nakayama, A. Otani, et al.

Discover the groundbreaking fluorescent labeling reagent, TAP-VK1, developed by Atsushi Nakayama and colleagues, which specifically reacts with aliphatic thiols, significantly boosting fluorescence intensity. This innovative approach has enabled effective fluorescence imaging of Captopril in living cells, showcasing a leap in chemical sensing technology.

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Playback language: English
Abstract
This paper reports the development of a compact fluorescent labeling reagent, 2-isobutenylcarbonyl-1,3a,6a-triazapentalene (TAP-VK1), derived from 1,3a,6a-triazapentalenes. TAP-VK1 reacts specifically with aliphatic thiols, exhibiting a significant increase in fluorescence intensity after thiol addition. Its utility is demonstrated through the successful fluorescence imaging of Captopril, a small molecule drug, in living cells.
Publisher
Communications Chemistry
Published On
Jan 09, 2020
Authors
Atsushi Nakayama, Akira Otani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Akira Nakayama, Kohji Itoh, Akira Otaka, Keiji Tanino, Kosuke Namba
Tags
fluorescent labeling reagent
TAP-VK1
aliphatic thiols
fluorescence imaging
Captopril
living cells
chemical sensing

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