*Clostridioides difficile* infections are a significant global health problem. This study focuses on developing peptide inhibitors to block Toxin A (*C. diff*). Using a combination of peptide binding design algorithms, molecular simulations, assays evaluating peptide-toxin binding, and surface plasmon resonance measurements, the researchers identified a peptide, SA1, that effectively blocks Toxin A in human colon epithelial cells. SA1 displays a K<sub>D</sub> of 56.1 ± 29.8 nM.
Publisher
Communications Biology
Published On
Aug 26, 2023
Authors
Sudeep Sarma, Carly M. Catella, Ellyce T. San Pedro, Xingqing Xiao, Deniz Durmusoglu, Stefano Menegatti, Nathan Crook, Scott T. Magness, Carol K. Hall
Tags
Clostridioides difficile
Toxin A
peptide inhibitors
human colon epithelial cells
binding affinity
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