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Abstract
This study investigated the effects of the prebiotic xylooligosaccharide (XOS) on gut microbiota and ear inflammation in a murine model of oxazolone-induced atopic dermatitis. Mice fed an XOS-supplemented diet showed significantly fewer high responders to dermatitis compared to controls. XOS-fed mice also exhibited higher abundances of *Prevotella* spp. in their gut microbiota. A strong association between the low-responding phenotype and high *Prevotella* abundance suggests an anti-inflammatory role for this bacterium in allergic sensitization, highlighting it as a potential target for microbiota-directed therapies.
Publisher
Scientific Reports
Published On
Dec 03, 2020
Authors
Ann Laigaard, Lukasz Krych, Line F. Zachariassen, Lea Ellegaard-Jensen, Dennis S. Nielsen, Axel K. Hansen, Camilla H. F. Hansen
Tags
xylooligosaccharide
gut microbiota
atopic dermatitis
Prevotella
anti-inflammatory
murine model
allergic sensitization

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