Medicine and Health

Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue

S. Park, M. G. Kook, et al.

Discover the groundbreaking development of a 3D multicellular testis-on-a-chip platform created by Se-Ra Park and colleagues. This innovative model intricately mimics the interactions between Sertoli and Leydig cells, enhancing our understanding of spermatogenesis and reproductive toxicity screening.

00:00

Playback language: English

Index

Abstract

This research paper details the development of a 3D multicellular testis-on-a-chip platform that accurately replicates the reciprocal crosstalk between Sertoli and Leydig cells, crucial for spermatogenesis. The platform incorporates various human testicular tissue cells and natural polymers with blood coagulation factors. SERPINB2 is identified as a biomarker for male reproductive toxicity, and a fluorescent reporter system is integrated to assess material toxicity. This testis-on-a-chip model offers advancements in toxicity screening and reproductive research.

Publisher

Experimental & Molecular Medicine

Published On

Jul 01, 2024

Authors

Se-Ra Park, Myung Geun Kook, Soo-Rim Kim, Choon-Mi Lee, Jin Woo Lee, Jung-Kyu Park, Chan Hum Park, Byung-Chul Oh, YunJae Jung, In-Sun Hong

Related Publications

Explore these studies to deepen your understanding of the subject.

Humanities

“I’m all that stands between them and chaos:” a monstrous way of ruling in *A Song of Ice and Fire*

G. Kovács

Psychology

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

Q. Liu and J. Li

Medicine and Health

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

A. Lang, O. Kuss, et al.

Medicine and Health

MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids

A. Tworak, R. Smidak, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny