Medicine and Health

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

S. T. Bond, E. J. King, et al.

Discover how Trim28 influences post-developmental adiposity, particularly in females, in this groundbreaking research by Simon T. Bond and colleagues. Their findings unveil the complex interplay between lipolysis and metabolic regulation, shedding light on potential implications for obesity treatment.

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Playback language: English

Index

Abstract

This study investigates the role of Trim28, a transcriptional corepressor, in post-developmental adiposity. Mice with adipocyte-specific Trim28 deletion developed obesity, particularly in females, without impaired glucose tolerance. Mechanistically, this involved altered lipolysis and triglyceride metabolism, potentially due to Klf14 downregulation, a known sex-specific metabolic regulator. The findings highlight Trim28 as a sex-specific regulator of post-developmental adiposity and WAT function.

Publisher

Nature Communications

Published On

Jan 04, 2021

Authors

Simon T. Bond, Emily J. King, Darren C. Henstridge, Adrian Tran, Sarah C. Moody, Christine Yang, Yingying Liu, Natalie A. Mellett, Artika P. Nath, Michael Inouye, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Peter J. Meikle, Anna C. Calkin, Brian G. Drew

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