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Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Food Science and Technology

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

S. Panyod, W. Wu, et al.

This study by Suraphan Panyod and colleagues uncovers troubling effects of common dietary emulsifiers on mice, revealing their potential to induce metabolic disorders and alter gut microbiota. The findings spark safety concerns about these widely used additives, particularly their role in metabolic syndrome.

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Playback language: English
Abstract
This study investigates the impact of common dietary emulsifiers (lecithin, sucrose fatty acid esters, carboxymethylcellulose (CMC), and mono- and diglycerides (MDG)) on metabolic disorders and gut microbiota in mice. Sucrose fatty acid esters and CMC induced hyperglycemia and hyperinsulinemia. All emulsifiers altered gut microbiota diversity, with MDG showing bacterial encroachment into the mucus layer and increased circulating lipopolysaccharide. The findings raise safety concerns regarding the use of these emulsifiers and their potential contribution to metabolic syndrome.
Publisher
Communications Biology
Published On
Jun 20, 2024
Authors
Suraphan Panyod, Wei-Kai Wu, Chih-Ting Chang, Naohisa Wada, Han-Chen Ho, Yi-Ling Lo, Sing-Ping Tsai, Rou-An Chen, Huai-Syuan Huang, Po-Yu Liu, Yi-Hsun Chen, Hsiao-Li Chuang, Ting-Chin David Shen, Sen-Lin Tang, Chi-Tang Ho, Ming-Shiang Wu, Lee-Yan Sheen
Tags
dietary emulsifiers
metabolic disorders
gut microbiota
hyperglycemia
safety concerns
mice study

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