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Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice

Health and Fitness

Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice

J. A. Wali, D. Ni, et al.

This fascinating study conducted by Jibran A. Wali and colleagues explores how dietary fat and sugars influence metabolic health in mice. Notably, a 50:50 mixture of fructose and glucose was found to be more obesogenic at lower fat levels, while high fat consumption generally worsened glucose tolerance and insulin sensitivity.

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Playback language: English
Abstract
This study investigates the interaction between dietary fat and sugars (fructose and glucose) on metabolic health using nutritional geometry. Male mice (n=245) were fed 18 isocaloric diets for 18-19 weeks. A 50:50 fructose-glucose mixture was more obesogenic at low-medium fat levels than monosaccharides alone. High fat intake generally worsened glucose tolerance and insulin sensitivity regardless of sugar composition. Fat source (soy oil vs. lard) didn't significantly alter outcomes. The study reconciles aspects of energy balance and carbohydrate-insulin models of obesity.
Publisher
Nature Communications
Published On
Jul 21, 2023
Authors
Jibran A. Wali, Duan Ni, Harrison J. W. Facey, Tim Dodgson, Tamara J. Pulpitel, Alistair M. Senior, David Raubenheimer, Laurence Macia, Stephen J. Simpson
Tags
dietary fat
sugars
metabolic health
obesity
glucose tolerance
insulin sensitivity
nutritional geometry

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