An engineered ACE2 decoy neutralizes SARS-CoV-2 Omicron BA.5 in | ResearchBunny

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Abstract

SARS-CoV-2 continues to evolve, evading antibody responses. This study designed a soluble ACE2 (sACE2) decoy, FLIF, using computational methods. FLIF exhibits picomolar affinity for Delta and Omicron variants, effectively neutralizing BA.5 in vitro and in vivo. The study demonstrates the potential of FLIF as a pan-coronavirus therapeutic.

Publisher

Communications Biology

Published On

May 12, 2023

Authors

Havranek, B., Lee, G. W., Procko, E., Higuchi, Y., Harada, A., Ikemura, N., Sasaki, T., Ohmagari, N., Islam, S. M.

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