Medicine and Health

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

A. A. Ordonez, C. K. Bullen, et al.

Discover the promising antiviral effects of sulforaphane (SFN), a phytochemical in cruciferous vegetables. This innovative research by Alvaro A. Ordonez and colleagues at Johns Hopkins University showcases SFN's ability to combat SARS-CoV-2 and HCoV-OC43, demonstrating significant reductions in viral load and lung injury in mice. A potential breakthrough in the prevention and treatment of coronavirus infections awaits.

00:00

Playback language: English

Index

Abstract

This study evaluated the antiviral activity of sulforaphane (SFN), a phytochemical found in cruciferous vegetables, against SARS-CoV-2 and HCoV-OC43. SFN inhibited in vitro replication of multiple SARS-CoV-2 strains, including Delta and Omicron, and HCoV-OC43. SFN and remdesivir showed synergistic antiviral effects. Prophylactic SFN treatment in mice significantly reduced viral load, lung injury, and pulmonary pathology, and diminished immune cell activation in the lungs. These results suggest SFN's potential as a preventative or therapeutic agent for coronavirus infections.

Publisher

Communications Biology

Published On

Mar 18, 2022

Authors

Alvaro A. Ordonez, C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken, Sanjay K. Jain, Lorraine Jones-Brando

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice

A. S. Ashhurst, M. D. Johansen, et al.

Biology

Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia

J. Y. L. Fu, M. H. Pukhari, et al.

Medicine and Health

An engineered ACE2 decoy neutralizes SARS-CoV-2 Omicron BA.5 in vitro and in vivo

H. B., L. G. W., et al.

Medicine and Health

A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

L. M. Coria, J. M. Rodriguez, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny