Medicine and Health

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

A. A. Ordonez, C. K. Bullen, et al.

Discover the promising antiviral effects of sulforaphane (SFN), a phytochemical in cruciferous vegetables. This innovative research by Alvaro A. Ordonez and colleagues at Johns Hopkins University showcases SFN's ability to combat SARS-CoV-2 and HCoV-OC43, demonstrating significant reductions in viral load and lung injury in mice. A potential breakthrough in the prevention and treatment of coronavirus infections awaits.

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Abstract

This study evaluated the antiviral activity of sulforaphane (SFN), a phytochemical found in cruciferous vegetables, against SARS-CoV-2 and HCoV-OC43. SFN inhibited in vitro replication of multiple SARS-CoV-2 strains, including Delta and Omicron, and HCoV-OC43. SFN and remdesivir showed synergistic antiviral effects. Prophylactic SFN treatment in mice significantly reduced viral load, lung injury, and pulmonary pathology, and diminished immune cell activation in the lungs. These results suggest SFN's potential as a preventative or therapeutic agent for coronavirus infections.

Publisher

Communications Biology

Published On

Mar 18, 2022

Authors

Alvaro A. Ordonez, C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken, Sanjay K. Jain, Lorraine Jones-Brando

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