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An engineered ACE2 decoy neutralizes SARS-CoV-2 Omicron BA.5 in vitro and in vivo

Medicine and Health

An engineered ACE2 decoy neutralizes SARS-CoV-2 Omicron BA.5 in vitro and in vivo

H. B., L. G. W., et al.

SARS-CoV-2 continues to evolve, challenging antibody responses. Researchers, including Havranek, Lee, Procko, and others, have developed FLIF, a soluble ACE2 decoy that showcases remarkable neutralization capabilities against the Delta and Omicron variants, including BA.5. This innovative approach has the potential to serve as a therapeutic solution for coronaviruses.

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Playback language: English
Abstract
SARS-CoV-2 continues to evolve, evading antibody responses. This study designed a soluble ACE2 (sACE2) decoy, FLIF, using computational methods. FLIF exhibits picomolar affinity for Delta and Omicron variants, effectively neutralizing BA.5 in vitro and in vivo. The study demonstrates the potential of FLIF as a pan-coronavirus therapeutic.
Publisher
Communications Biology
Published On
May 12, 2023
Authors
Havranek, B., Lee, G. W., Procko, E., Higuchi, Y., Harada, A., Ikemura, N., Sasaki, T., Ohmagari, N., Islam, S. M.
Tags
SARS-CoV-2
soluble ACE2
FLIF
Delta variant
Omicron variant
therapeutic
neutralization

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