Engineering and Technology

Tough and biodegradable polyurethane-silica hybrids with a rapid sol-gel transition for bone repair

S. J. Park, S. H. Im, et al.

Discover groundbreaking research by Su Jeong Park and colleagues on a novel biodegradable polyurethane-silica hybrid that showcases remarkable flexibility, biodegradability, and a unique shape memory ability. This innovative work accelerates bone regeneration through osteogenic differentiation and angiogenesis, promising exciting advancements in tissue engineering.

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Playback language: English

Index

Abstract

This study synthesized a novel polycaprolactone (PCL)-based polyurethane (PU) with an organosilane functional group and produced a biodegradable PU-silica hybrid via the sol-gel process. The resulting hybrid exhibited flexibility, biodegradability, and shape memory ability. Allophanate bonding facilitated rapid sol-gel transition, enabling the creation of 3D porous scaffolds using a salt-leaching process. A 30 wt.% silica hybrid scaffold demonstrated optimal mechanical properties and induced osteogenic differentiation and angiogenesis, accelerating bone regeneration.

Publisher

NPG Asia Materials

Published On

Mar 01, 2023

Authors

Su Jeong Park, Seung Hyuk Im, Donghak Kim, DoYeun Park, Youngmee Jung, Hyung-seop Han, Soo Hyun Kim, Justin J. Chung

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