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The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

Medicine and Health

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

M. P. Alves, C. G. Benaraï, et al.

Discover how Omicron-BA.1 compares to VOC Delta in human cells and animal models in this intriguing study by Marco P. Alves, Charles Gérard Benaraï, Martin Beer, and Volker Thiel. The research reveals Omicron's enhanced replication in nasal cells but limited in bronchial ones, raising questions about its immune evasion strategies.

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Playback language: English
Abstract
This study characterizes Omicron-BA.1 and its recombinant spike gene mutants compared to VOC Delta in primary human cells and animal models. Omicron-BA.1 showed enhanced early replication in nasal epithelial cells but limited replication in bronchial cells. Delta dominated over Omicron-BA.1 in hamsters and ferrets. In hACE2-knock-in mice, Delta and its spike clone outperformed Omicron-BA.1 and its clone. However, in naïve K18-hACE2 mice, Omicron-BA.1 showed reduced replication and pathogenicity. The Omicron-BA.1 spike clone was less controlled by mRNA vaccination, highlighting immune evasion as a factor in its dominance.
Publisher
Nature Communications
Published On
Oct 07, 2022
Authors
Marco P. Alves, Charles Gérard Benaraï, Martin Beer, Volker Thiel
Tags
Omicron-BA.1
Delta variant
replication dynamics
immune evasion
animal models
human cells
spike gene mutants

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