logo
ResearchBunny Logo
Abstract
SARS-CoV-2 papain-like protease (PLpro) plays crucial roles in viral maturation and immune response dysregulation, making it a promising drug target. This study screened a drug library, identifying GRL0617 as a potent PLpro inhibitor. The co-crystal structure of SARS-CoV-2 PLpro with GRL0617 reveals a non-covalent interaction within the USP domain. NMR data demonstrates GRL0617 blocks ISG15 C-terminus binding to PLpro, highlighting this pocket as a crucial hot spot for antiviral drug development.
Publisher
Nature Communications
Published On
Jan 20, 2021
Authors
Ziyang Fu, Bin Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenning Zhu, Dan Cao, Jihui Li, Xiaogang Niu, Huan Zhou, Yong Juan Zhao, Guoliang Zhang, Hao Huang
Tags
SARS-CoV-2
PLpro inhibitor
GRL0617
antiviral drug
structural biology
NMR
immune response

Related Publications

Explore these studies to deepen your understanding of the subject.

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)
Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
Medicine and Health

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

L. Wu, Q. Chen, et al.

The COVID-AGICT study: COVID-19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes
Medicine and Health

The COVID-AGICT study: COVID-19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes

G. Giuliani, F. Guerra, et al.

Media events, speech events and propagandistic techniques of legitimation: a multimodal analysis of the Greek Prime Minister Kyriakos Mitsotakis' public addresses on the SARS-CoV-2 pandemic
Political Science

Media events, speech events and propagandistic techniques of legitimation: a multimodal analysis of the Greek Prime Minister Kyriakos Mitsotakis' public addresses on the SARS-CoV-2 pandemic

S. Poulakidakos

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny