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The reaction mechanism of the *Ideonella sakaiensis* PETase enzyme

Chemistry

The reaction mechanism of the *Ideonella sakaiensis* PETase enzyme

T. Burgin, B. C. Pollard, et al.

Discover the groundbreaking research by Tucker Burgin and team that uncovers the intricate multi-step catalytic mechanism of the *Ideonella sakaiensis* PETase enzyme, crucial for tackling plastic waste. This study reveals a pivotal rate-limiting step and highlights the flexibility of Trp185, offering valuable insights for future enzyme engineering in plastics bioconversion.

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