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The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair

Medicine and Health

The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair

Y. Wang, L. H. Koole, et al.

This innovative study conducted by Yili Wang and colleagues explores the potential of photo-polymerizable gelatin and hyaluronic acid hydrogels enriched with decellularized cartilage matrix from gene knockout pigs for effective cartilage repair. The findings indicate improved properties of the hydrogels and promising outcomes in cartilage regeneration.

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Playback language: English
Abstract
This study investigates the use of photo-polymerizable gelatin (Gel) and hyaluronic acid (HA) hydrogels, incorporating decellularized cartilage matrix (DCM) from α-1,3-galactose gene knockout pigs, for cartilage repair. The hydrogels were characterized for their physicochemical properties and biocompatibility. In vitro studies assessed cytotoxicity, cell morphology, and chondrogenic differentiation. In vivo performance was evaluated in a rat knee cartilage defect model. Results suggest that the addition of DCM enhances the hydrogels' properties and promotes cartilage regeneration.
Publisher
npj Regenerative Medicine
Published On
Sep 10, 2021
Authors
Yili Wang, Levinus Hendrik Koole, Cenyuan Gao, Dejun Yang, Lei Yang, Chunwu Zhang, Huaqiong Li
Tags
photo-polymerizable gelatin
hyaluronic acid
cartilage repair
decellularized cartilage matrix
chondrogenic differentiation
biocompatibility

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