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Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy
Medicine and HealthNature Communications

Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy

Y. Li, Y. Cong, et al.

Exciting advancements in cancer therapy are on the horizon! This study by Ying Li and colleagues reveals that an innovative IL-21-anti-PD-1 antibody fusion protein significantly enhances memory T cell generation and boosts antitumor effects in mice, surpassing traditional PD-1 blockade methods. Discover how this could reshape immune checkpoint therapies!... show more
Abstract
Publisher
Nature Communications
Published On
Feb 01, 2021
Authors
Ying Li, Yanni Cong, Mingming Jia, Qianian He, Haiqing Zhong, Yun Zhao, Hang Li, Meining Yan, Jia You, Jia Liu, Lieping Chen, Haiying Hang, Shengdan Wang
Tags
PD-1 blockadeIL-21antitumor therapyT cellsimmune checkpointcancer therapy
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