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IL-15 armoring enhances the antitumor efficacy of claudin 18.2-targeting CAR-T cells in syngeneic mouse tumor models

Medicine and Health

IL-15 armoring enhances the antitumor efficacy of claudin 18.2-targeting CAR-T cells in syngeneic mouse tumor models

H. Shi, A. Li, et al.

Discover how IL-15-armored claudin 18.2-targeting CAR-T cells are revolutionizing antitumor therapy in pancreatic and melanoma models. This groundbreaking study led by Hongtai Shi, Andi Li, Zhenyu Dai, and others showcases enhanced in vitro expansion and surprising tumor angiogenesis, indicating a promising direction for solid tumor treatments.

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Abstract
Publisher
Frontiers in Immunology
Published On
Oct 26, 2023
Authors
Hongtai Shi, Andi Li, Zhenyu Dai, Jiao Xue, Qi Zhao, Jiyuan Tian, Dandan Song, Hao Wang, Jianan Chen, Xiaokang Zhang, Kaisong Zhou, Huafeng Wei, Songbing Qin
Tags
CAR-T cells
IL-15 armoring
antitumor efficacy
solid tumors
tumor angiogenesis
pancreatic cancer
melanoma

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