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TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy

Medicine and Health

TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy

C. Gonzalez, S. Williamson, et al.

This groundbreaking study by Caleb Gonzalez, Sarah Williamson, Seth T. Gammon, Sarah Glazer, Joon Haeng Rhee, and David Piwinca-Worms explores how TLR5 agonists like flagellin and CBLB502 can significantly enhance survival rates when combined with immune checkpoint inhibitors against tough cancer types, such as triple-negative breast cancer and melanoma. The findings reveal promising new strategies to tackle cancer resistance and build long-term immunological memory.

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Playback language: English
Abstract
This study investigated the efficacy of TLR5 agonists, flagellin and CBLB502, in combination with immune checkpoint inhibitors (ICT) against highly refractory triple-negative breast cancer (4T1) and melanoma (B16-F10) tumors in mice. Intratumoral administration of TLR5 agonists significantly enhanced survival when combined with ICT, demonstrating long-term survival and immunological memory. Specific cytokine profiles, particularly low G-CSF and CXCL5 levels and high IL-15, correlated with enhanced survival. The study suggests a novel therapeutic strategy using TLR5 agonists to overcome ICT resistance in solid tumors.
Publisher
Communications Biology
Published On
Jan 12, 2023
Authors
Caleb Gonzalez, Sarah Williamson, Seth T. Gammon, Sarah Glazer, Joon Haeng Rhee, David Piwinca-Worms
Tags
TLR5 agonists
immune checkpoint inhibitors
triple-negative breast cancer
melanoma
survival rates
cytokine profiles
immunological memory

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