Food Science and Technology

Systematic evaluation of antimicrobial food preservatives on glucose metabolism and gut microbiota in healthy mice

P. Li, M. Li, et al.

This study reveals the surprising impact of common antimicrobial preservatives on glucose metabolism and gut microbiota in healthy mice. Conducted by a team from the State Key Laboratory of Food Science and Technology, Nanchang University, the research highlights that even biogenic preservatives like nisin can lead to significant metabolic disruptions.

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Abstract

This study investigated the effects of eleven common antimicrobial preservatives (APs), both synthetic and biogenic, on glucose metabolism and gut microbiota in healthy mice. The results showed that chronic AP consumption induced glucose intolerance and altered gut microbiota composition, regardless of the AP's origin. Biogenic APs were not consistently safer than synthetic ones; nisin, a biogenic AP, caused the most significant effects, potentially through disruption of glucagon-like peptide 1 (GLP-1) related glucoregulatory hormone secretion.

Publisher

npj Science of Food

Published On

Sep 13, 2022

Authors

Ping Li, Ming Li, Tao Wu, Ying Song, Yan Li, Xiaochang Huang, Hui Lu, Zhenjiang Zech Xu

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