Biology
Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions
A. Nag, A. Mafi, et al.
Uncover the potential of macrocycle peptides in targeting intracellular proteins with the development of a high-affinity peptide ligand that effectively penetrates cell membranes. This groundbreaking research by Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A. Goddard III, and James R. Heath provides insights into cell-penetrant ligands and their interactions with cholesterol, expanding the toolkit for drug design.
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