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speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Medicine and Health

speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

R. Castellanos-rueda, R. B. D. Roberto, et al.

This groundbreaking research by Rocío Castellanos-Rueda, Raphaël B. Di Roberto, and others showcases speedingCARs, a novel method that utilizes engineered chimeric antigen receptors for enhanced T cell responses against tumors. By integrating a diverse library of CAR variants into human T cells, the study identifies potentiated tumor-killing properties through advanced sequencing techniques, paving the way for innovative cancer therapies.

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