logo
ResearchBunny Logo
Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the 'Bystander' Activation of Memory CD8 + T Cells

Medicine and Health

Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the 'Bystander' Activation of Memory CD8 + T Cells

S. Santillo, Damiano, et al.

Explore the intricate relationship between mitochondrial melatonin pathways, gut microbiome interactions, and immune responses in Type 1 diabetes mellitus as reviewed by Simona Santillo, Damiano, and George Anderson. Discover how these factors interplay, leading to β-cell apoptosis and autoimmune effects.

00:00
00:00
Playback language: English
Abstract
Type 1 diabetes mellitus (T1DM) results from pancreatic β-cell failure to produce sufficient insulin, often due to β-cell destruction. This review examines T1DM pathophysiology, emphasizing the role of mitochondrial melatonin pathways in pancreatic β-cells, gut microbiome interactions, and bystander activation of memory CD8+ T cells. Mitochondrial melatonin suppression renders β-cells vulnerable to oxidative stress and dysfunctional mitophagy. Gut dysbiosis and permeability affect immune responses and mitochondrial function. The interplay between these factors contributes to β-cell apoptosis and autoimmune effects.
Publisher
International Journal of Molecular Sciences
Published On
Feb 07, 2023
Authors
Simona Santillo, Damiano, George Anderson
Tags
Type 1 diabetes mellitus
mitochondrial melatonin
gut microbiome
β-cell apoptosis
immune response
oxidative stress
autoimmunity
Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny