Biology

Single-particle cryo-EM structures from IDPC-STEM at near-atomic resolution

I. Lazić, M. Wirix, et al.

This groundbreaking study showcases the potential of integrated differential phase contrast scanning transmission electron microscopy (IDPC-STEM) for high-resolution structure determination in cryo-electron microscopy. By examining keyhole limpet hemocyanin and tobacco mosaic virus, the researchers achieved near-atomic resolution, establishing IDPC-STEM as a powerful tool for biological macromolecule analysis. This research was conducted by Ivan Lazić, Maarten Wirix, Max Leo Leidl, Felix de Haas, Daniel Mann, Maximilian Beckers, Evgeniya V. Pechnikova, Knut Müller-Caspary, Ricardo Egoavil, Eric G. T. Bosch, and Carsten Sachse.