Medicine and Health

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

S. Cai, T. Pataillot-meakin, et al.

This groundbreaking research by Shenglin Cai and colleagues introduces size-encoded molecular probes that allow for electro-optical nanopore sensing of microRNAs in unprocessed human serum. Achieving remarkable sensitivity and specificity, this innovative approach may revolutionize cancer diagnostics.

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Abstract

This study develops size-encoded molecular probes for simultaneous electro-optical nanopore sensing of microRNAs (miRNAs), enabling ultrasensitive, sequence-specific, and multiplexed detection directly in unprocessed human serum. The approach achieves femtomolar sensitivity and single-base mismatch selectivity, successfully monitoring miR-141-3p and miR-375-3p in prostate cancer patients with active disease and in remission. This technology offers a promising minimally invasive diagnostic tool for cancer.

Publisher

Nature Communications

Published On

Jun 10, 2021

Authors

Shenglin Cai, Thomas Pataillot-Meakin, Akifumi Shibakawa, Ren Ren, Charlotte L. Bevan, Sylvain Ladame, Aleksandar P. Ivanov, Joshua B. Edel

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