Chemistry

Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry

T. P. Wörner, K. Aizikov, et al.

Explore groundbreaking advancements in charge-detection mass spectrometry! This research dives into the behavior of single macromolecular ions in an Orbitrap analyzer, revealing remarkable stability and improved mass precision achieved by authors Tobias P. Wörner, Konstantin Aizikov, Joost Snijder, Kyle L. Fort, Alexander A. Makarov, and Albert J. R. Heck.

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Abstract

To enhance charge-detection mass spectrometry (CDMS), the behavior of single macromolecular ions in an Orbitrap analyzer was investigated. Megadalton ions showed remarkable stability, enabling precise mass analysis with resolution >100,000. Monitoring individual ion frequencies revealed gradual solvent loss and rare charge stripping. Correcting for frequency drift improved ion sampling 23-fold, leading to a twofold increase in mass precision and resolution.

Publisher

Nature Chemistry

Published On

Mar 10, 2022

Authors

Tobias P. Wörner, Konstantin Aizikov, Joost Snijder, Kyle L. Fort, Alexander A. Makarov, Albert J. R. Heck

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