Medicine and Health

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

P. Arner, N. Viguerie, et al.

This study delves into the sex differences in adipose tissue insulin resistance, highlighting how obesity affects men and women differently. Conducted by notable researchers including Peter Arner and Nathalie Viguerie, the findings reveal that in obesity, men face greater adipose insulin resistance, marked by lower insulin sensitivity and altered lipolysis processes.

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Abstract

This study investigated sex differences in adipose tissue insulin resistance. Men showed higher AdipolR values (an in vivo adipose insulin resistance index) than women, but only in the presence of obesity. In obese individuals, men exhibited lower adipocyte insulin sensitivity and maximal antilipolytic effect, along with a higher basal lipolysis rate. RNA sequencing revealed lower expression of insulin receptor substrate 1 (IRS1) in men. The findings suggest that in obesity, men's greater adipose insulin resistance involves less effective insulin inhibition of lipolysis, increased basal lipolysis, and reduced adipose IRS1 expression.

Publisher

International Journal of Obesity

Published On

Mar 15, 2024

Authors

Peter Arner, Nathalie Viguerie, Lucas Massier, Mikael Rydén, Arne Astrup, Ellen Blaak, Dominique Langin, Daniel Peter Andersson

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