Medicine and Health

DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

P. Baca, F. Barajas-olmos, et al.

This fascinating study by Paulina Baca and colleagues examines the role of DNA methylation in the visceral adipose tissue of obese women and its connection to type 2 diabetes risk. With significant discoveries in gene expression and methylation changes, the research highlights potential biomarkers for T2D susceptibility, paving the way for innovative approaches in tackling obesity-related health issues.

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Abstract

This study investigated DNA methylation and gene expression changes in visceral adipose tissue (VAT) from obese women with and without type 2 diabetes (T2D) to identify epigenetic factors contributing to T2D susceptibility. Genome-scale methylation and gene expression analyses revealed significant differences between the groups, with alterations in DNA methylation and gene expression profiles observed in several genes, including ATP11A, LPL, and EHD2. These findings suggest that DNA methylation could serve as a potential biomarker for T2D risk in obese individuals.

Publisher

Nutrition & Diabetes

Published On

Dec 19, 2022

Authors

Paulina Baca, Francisco Barajas-Olmos, Elaheh Mirzaeicheshmeh, Carlos Zerrweck, Lizbeth Guilbert, Ernesto Carlos Sánchez, Marlen Flores-Huacuja, Rafael Villafán, Angélica Martínez-Hernández, Humberto García-Ortiz, Cecilia Contreras-Cubas, Federico Centeno-Cruz, Lorena Orozco

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