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Abstract
This study investigated DNA methylation and gene expression changes in visceral adipose tissue (VAT) from obese women with and without type 2 diabetes (T2D) to identify epigenetic factors contributing to T2D susceptibility. Genome-scale methylation and gene expression analyses revealed significant differences between the groups, with alterations in DNA methylation and gene expression profiles observed in several genes, including ATP11A, LPL, and EHD2. These findings suggest that DNA methylation could serve as a potential biomarker for T2D risk in obese individuals.
Publisher
Nutrition & Diabetes
Published On
Dec 19, 2022
Authors
Paulina Baca, Francisco Barajas-Olmos, Elaheh Mirzaeicheshmeh, Carlos Zerrweck, Lizbeth Guilbert, Ernesto Carlos Sánchez, Marlen Flores-Huacuja, Rafael Villafán, Angélica Martínez-Hernández, Humberto García-Ortiz, Cecilia Contreras-Cubas, Federico Centeno-Cruz, Lorena Orozco
Tags
DNA methylation
gene expression
visceral adipose tissue
type 2 diabetes
obesity
epigenetic factors
biomarkers

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