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Abstract
This study investigated the function of peripancreatic adipose tissue (PAT) in lean and high-fat-diet (HFD)-induced obese mice. PAT, a small visceral fat depot, exhibited increased glucose uptake and fatty acid oxidation compared to other adipose tissue depots. Surgical removal of PAT in HFD-fed mice resulted in aggravated hepatic steatosis and increased insulin levels, suggesting a protective role of PAT against metabolic disturbances in obesity.
Publisher
Scientific Reports
Published On
Aug 25, 2020
Authors
Belén Chanclón, Yanling Wu, Milica Vujičić, Marco Bauzá-Thorbrügge, Elin Banke, Peter Micallef, Julia Kanerva, Björn Wilder, Patrik Rorsman, Ingrid Wernstedt Asterholm
Tags
peripancreatic adipose tissue
glucose uptake
fatty acid oxidation
obesity
metabolic disturbances
hepatic steatosis
insulin levels

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