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Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice

Medicine and Health

Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice

B. Chanclón, Y. Wu, et al.

Discover how peripancreatic adipose tissue (PAT) plays a protective role against metabolic disturbances in obesity. This exciting research by Belén Chanclón and colleagues uncovers the enhanced glucose uptake and fatty acid oxidation of PAT in both lean and high-fat-diet-induced obese mice, highlighting its significance in combating obesity-related issues.

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Playback language: English
Abstract
This study investigated the function of peripancreatic adipose tissue (PAT) in lean and high-fat-diet (HFD)-induced obese mice. PAT, a small visceral fat depot, exhibited increased glucose uptake and fatty acid oxidation compared to other adipose tissue depots. Surgical removal of PAT in HFD-fed mice resulted in aggravated hepatic steatosis and increased insulin levels, suggesting a protective role of PAT against metabolic disturbances in obesity.
Publisher
Scientific Reports
Published On
Aug 25, 2020
Authors
Belén Chanclón, Yanling Wu, Milica Vujičić, Marco Bauzá-Thorbrügge, Elin Banke, Peter Micallef, Julia Kanerva, Björn Wilder, Patrik Rorsman, Ingrid Wernstedt Asterholm
Tags
peripancreatic adipose tissue
glucose uptake
fatty acid oxidation
obesity
metabolic disturbances
hepatic steatosis
insulin levels

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