Medicine and Health

Semen Ziziphi Spinosae attenuates blood-brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

H. Liu, X. Zhang, et al.

Discover how Semen Ziziphi Spinosae (SZS) protects the brain by repairing lipopolysaccharide-induced blood-brain barrier dysfunction. This groundbreaking research by Huayan Liu, Xin Zhang, Yujiao Liu, Nian Xin, Yulin Deng, and Yujuan Li reveals a pathway that could transform our approach to cerebral diseases and functional foods.

00:00

Playback language: English

Index

Abstract

Semen Ziziphi Spinosae (SZS) demonstrates neuroprotective effects by attenuating lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) dysfunction. Proteomic analysis revealed that SZS significantly altered 135 proteins in rat brains, primarily affecting cell-cell adhesion and adherens junctions. SZS reversed LPS-induced BBB breakdown by activating the FAK-DOCK180-Rac1-WAVE2-Arp3 pathway. Molecular docking studies indicated that SZS components, such as 6''-feruloylspinosin, spinosin, and swertisin, strongly bind to signaling pathway proteins. These findings suggest SZS's potential in preventing cerebral diseases and its further application as a functional food.

Publisher

npj Science of Food

Published On

Jun 02, 2022

Authors

Huayan Liu, Xin Zhang, Yujiao Liu, Nian Xin, Yulin Deng, Yujuan Li

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Influence of stress induced by the first announced state of emergency due to coronavirus disease 2019 on outpatient blood pressure management in Japan

K. Kobayashi, K. Chin, et al.

Psychology

Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder

H. Hori, H. Fukushima, et al.

Biology

Viral proteins resolve the virus-vector conundrum during hemipteran-mediated transmission by subverting salicylic acid signaling pathway

J. Zhang, Y. Liu, et al.

Engineering and Technology

Towards Novel Biomimetic In Vitro Models of the Blood-Brain Barrier for Drug Permeability Evaluation

I. Mármol, S. Abizanda-campo, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny