Medicine and Health

Semen Ziziphi Spinosae attenuates blood-brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway

H. Liu, X. Zhang, et al.

Discover how Semen Ziziphi Spinosae (SZS) protects the brain by repairing lipopolysaccharide-induced blood-brain barrier dysfunction. This groundbreaking research by Huayan Liu, Xin Zhang, Yujiao Liu, Nian Xin, Yulin Deng, and Yujuan Li reveals a pathway that could transform our approach to cerebral diseases and functional foods.

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Playback language: English

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Abstract

Semen Ziziphi Spinosae (SZS) demonstrates neuroprotective effects by attenuating lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) dysfunction. Proteomic analysis revealed that SZS significantly altered 135 proteins in rat brains, primarily affecting cell-cell adhesion and adherens junctions. SZS reversed LPS-induced BBB breakdown by activating the FAK-DOCK180-Rac1-WAVE2-Arp3 pathway. Molecular docking studies indicated that SZS components, such as 6''-feruloylspinosin, spinosin, and swertisin, strongly bind to signaling pathway proteins. These findings suggest SZS's potential in preventing cerebral diseases and its further application as a functional food.

Publisher

npj Science of Food

Published On

Jun 02, 2022

Authors

Huayan Liu, Xin Zhang, Yujiao Liu, Nian Xin, Yulin Deng, Yujuan Li

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