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Abstract
This paper reports the self-assembly of trimetallic cryptands that encapsulate anions and exhibit metal-dependent differences in chemical and biological reactivities. Copper and zinc complexes demonstrated potent toxicity towards various human cancer cell lines, showing significant selectivity towards cancer cells over healthy cells (up to 2000-fold). Anion addition (PO₄³⁻, SO₄²⁻, PhOPO₃²⁻) modulated this activity and selectivity. The mechanism involves phosphate ester binding or hydrolysis and selective kinase inhibition via different mechanisms for copper and zinc complexes.
Publisher
Nature Communications
Published On
Jun 23, 2021
Authors
Simon J. Allison, Jarosław Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice
Tags
trimetallic cryptands
cancer cells
selective toxicity
anion modulation
biochemical mechanisms
copper complexes
zinc complexes

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