logo
ResearchBunny Logo
Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent *in vitro* anti-cancer properties

Chemistry

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent *in vitro* anti-cancer properties

S. J. Allison, J. Bryk, et al.

Discover the groundbreaking research conducted by Simon J. Allison and colleagues, showcasing trimetallic cryptands that not only encapsulate anions but also reveal significant metal-dependent variances in toxicity towards cancer cells, exhibiting remarkable selectivity. Anion modulation appears to control these effects, delving into complex biochemical mechanisms that could pave the way for innovative cancer therapies.

00:00
00:00
Playback language: English
Abstract
This paper reports the self-assembly of trimetallic cryptands that encapsulate anions and exhibit metal-dependent differences in chemical and biological reactivities. Copper and zinc complexes demonstrated potent toxicity towards various human cancer cell lines, showing significant selectivity towards cancer cells over healthy cells (up to 2000-fold). Anion addition (PO₄³⁻, SO₄²⁻, PhOPO₃²⁻) modulated this activity and selectivity. The mechanism involves phosphate ester binding or hydrolysis and selective kinase inhibition via different mechanisms for copper and zinc complexes.
Publisher
Nature Communications
Published On
Jun 23, 2021
Authors
Simon J. Allison, Jarosław Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice
Tags
trimetallic cryptands
cancer cells
selective toxicity
anion modulation
biochemical mechanisms
copper complexes
zinc complexes
Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny