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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Medicine and HealthNature Medicine

Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

N. J. Lennon, L. C. Kottyan, et al.

This groundbreaking study, conducted by a team of leading researchers, explores the transformative potential of polygenic risk scores (PRSs) in clinical settings. By creating a framework to implement PRS-based genome-informed risk assessments for a diverse population of 25,000 adults and children, the research tackles existing challenges and sheds light on the future of personalized medicine.... show more
Introduction
Literature Review
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Limitations
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