This study investigated the interaction between genetic factors and dietary patterns on kidney dysfunction in Korean adults. Using data from 8230 participants in the Ansan and Ansung Study of the Korean Genome and Epidemiology Study, a genome-wide association study identified 94 SNPs significantly associated with kidney dysfunction. Three dietary patterns were identified: "prudent pattern," "flour-based and animal food pattern," and "white rice pattern." The "flour-based and animal food pattern" showed a significant association with higher kidney dysfunction prevalence in both low and high genetic risk score (GRS) groups. These findings suggest personalized nutritional interventions based on GRS profiles may improve kidney dysfunction prevention.
Publisher
Nutrition and Diabetes
Published On
Aug 14, 2024
Authors
Min-Jae Jang, Li-Juan Tan, Min Young Park, Sangah Shin, Jun-Mo Kim
Tags
kidney dysfunction
genetic factors
dietary patterns
Korean adults
nutritional interventions
genome-wide association study
SNPs
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