Psychology

Saturated free fatty acids and association with memory formation

T. P. Wallis, B. G. Venkatesh, et al.

Discover how polyunsaturated free fatty acids impact memory formation! This groundbreaking study by Tristan P. Wallis and colleagues reveals the surprising role of saturated FFAs in auditory fear conditioning, highlighting the importance of NMDA receptor activation in the amygdala and prefrontal cortex.

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Abstract

Polyunsaturated free fatty acids (FFAs) are known to be beneficial for learning and memory. This study used a targeted lipidomics approach in rats to investigate the role of FFAs and phospholipids in memory formation, focusing on auditory fear conditioning. The results showed that auditory fear conditioning increased saturated FFAs (myristic and palmitic acids) in the amygdala and prefrontal cortex, a process dependent on NMDA receptor activation. This suggests a role for saturated FFAs in memory acquisition.

Publisher

Nature Communications

Published On

Jun 08, 2021

Authors

Tristan P. Wallis, Bharat G. Venkatesh, Vinod K. Narayana, David Kvaskoff, Alan Ho, Robert K. Sullivan, François Windels, Pankaj Sah, Frédéric A. Meunier

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