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The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Medicine and Health

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

F. Vanweert, S. C. Boone, et al.

This study reveals a fascinating link between plasma branched-chain amino acids and intrahepatic lipid content, regardless of physical activity levels. Conducted by a team of researchers including Froukje Vanweert and Sebastiaan C. Boone, the findings suggest that the reduction of intrahepatic lipids through exercise training is likely not dependent on changes in plasma branched-chain amino acids, particularly in individuals with type 2 diabetes and nonalcoholic fatty liver.

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Playback language: English
Abstract
This study aimed to evaluate the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) content, considering the influence of physical activity level and exercise training. A cross-sectional analysis of 1983 individuals showed a positive association between plasma BCAA levels and IHL, irrespective of physical activity. A 12-week exercise intervention in individuals with type 2 diabetes (T2DM), nonalcoholic fatty liver (NAFL), and controls demonstrated that exercise reduced IHL in NAFL and controls without altering plasma BCAA levels. Therefore, exercise training-induced IHL reduction is likely independent of changes in plasma BCAA levels.
Publisher
International Journal of Obesity
Published On
May 02, 2021
Authors
Froukje Vanweert, Sebastiaan C. Boone, Bram Brouwers, Dennis O. Mook-Kanamori, Renée de Mutsert, Frits R. Rosendaal, Hildo J. Lamb, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Matthijs K. C. Hesselink, Esther Phielix
Tags
branched-chain amino acids
intrahepatic lipid
exercise training
type 2 diabetes
nonalcoholic fatty liver
physical activity
metabolism

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