Medicine and Health

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

K. Sano, D. Bhavsar, et al.

This study reveals that mRNA vaccination generates stronger mucosal secretory IgA responses in individuals previously infected with SARS-CoV-2, enhancing their post-vaccination immunity. Conducted by a team of experts including Kaori Sano, Disha Bhavsar, and Viviana Simon, the findings are crucial in understanding vaccine efficacy in different populations.

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Abstract

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are more robustly induced in individuals with pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

Publisher

Nature Communications

Published On

Sep 01, 2022

Authors

Kaori Sano, Disha Bhavsar, Gagandeep Singh, Daniel Floda, Komal Srivastava, Charles Gleason, PARIS Study Group, Juan Manuel Carreño, Viviana Simon, Florian Krammer

DOI

https://doi.org/https://doi.org/10.1038/s41467-022-32389-8

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