Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. This study investigates maternal-fetal immune responses initiated by SARS-CoV-2 infection and the virus's detectability in the placenta. Results show SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, largely governed by maternal T cells and fetal stromal cells. Maternal blood shows humoral and cellular immune responses, while neonatal circulation shows a mild cytokine response. Importantly, SARS-CoV-2 is not detected in placental tissues, and placental sterility is not compromised.
Publisher
NATURE COMMUNICATIONS
Published On
Jan 18, 2022
Authors
Valeria Garcia-Flores, Roberto Romero, Yi Xu, Kevin R. Theis, Marcia Arenas-Hernandez, Derek Miller, Azam Peyvandipour, Gaurav Bhatti, Jose Galaz, Meyer Gershater, Dustyn Levenson, Errile Pusod, Li Tao, David Kracht, Violetta Florova, Yaozhu Leng, Kenichiro Motomura, Robert Para, Megan Faucett, Chaur-Dong Hsu, Gary Zhang, Adi L. Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez
Tags
SARS-CoV-2
Pregnancy
Maternal-fetal immune response
Inflammation
Placental sterility
Immunity
T cells
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