Medicine and Health

SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates

E. A. Murphy, C. Guzman-cardozo, et al.

This study by Elisabeth A. Murphy and colleagues reveals how SARS-CoV-2 vaccination and prior infections boost antibody levels in pregnant patients and their newborns. The research showcases a significant enhancement in neutralizing antibody activity against various SARS-CoV-2 variants, including Omicron, demonstrating the protective benefits of vaccination in both mothers and their babies.

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Index

Abstract

This study investigates the impact of SARS-CoV-2 vaccination, boosting, and infection history on antibody levels in pregnant patients and their neonates. Researchers measured spike-binding antibodies in 4600 patient-neonate pairs with varying vaccination statuses and infection histories, analyzing neutralizing antibody activity against different SARS-CoV-2 variants. Results show that vaccination and boosting, especially with prior infection, significantly increased antibody levels and neutralizing activity, even against Omicron BA.1 and BA.5 variants, in both mothers and their newborns.

Publisher

Nature Communications

Published On

Aug 10, 2023

Authors

Elisabeth A. Murphy, Camila Guzman-Cardozo, Ashley C. Sukhu, Debby J. Parks, Malavika Prabhu, Iman Mohammed, Magdalena Jurkiewicz, Thomas J. Ketas, Sunidhi Singh, Marie Canis, Eva Bednarski, Alexis Hollingsworth, Embree M. Thompson, Dorothy Eng, Paul D. Bieniasz, Laura E. Riley, Theodora Hatziioannou, Yawei J. Yang

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