This study investigates the impact of SARS-CoV-2 vaccination, boosting, and infection history on antibody levels in pregnant patients and their neonates. Researchers measured spike-binding antibodies in 4600 patient-neonate pairs with varying vaccination statuses and infection histories, analyzing neutralizing antibody activity against different SARS-CoV-2 variants. Results show that vaccination and boosting, especially with prior infection, significantly increased antibody levels and neutralizing activity, even against Omicron BA.1 and BA.5 variants, in both mothers and their newborns.
Publisher
Nature Communications
Published On
Aug 10, 2023
Authors
Elisabeth A. Murphy, Camila Guzman-Cardozo, Ashley C. Sukhu, Debby J. Parks, Malavika Prabhu, Iman Mohammed, Magdalena Jurkiewicz, Thomas J. Ketas, Sunidhi Singh, Marie Canis, Eva Bednarski, Alexis Hollingsworth, Embree M. Thompson, Dorothy Eng, Paul D. Bieniasz, Laura E. Riley, Theodora Hatziioannou, Yawei J. Yang
Tags
SARS-CoV-2
vaccination
antibody levels
pregnancy
neonates
neutralizing activity
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