Medicine and Health

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England

E. Copland, M. Patone, et al.

This comprehensive study led by Emma Copland, Martina Patone, and colleagues analyzes the risk-benefit profile of COVID-19 vaccination in children across England. The findings reveal a favorable safety profile, especially emphasizing minimal risks for younger children and comparing hospitalization rates for vaccinated versus unvaccinated kids.

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Abstract

This study investigated the risk-benefit profile of COVID-19 vaccination in children using linked data of 5.1 million children in England. In 5-11-year-olds, no increased risks of adverse events were found following vaccination. In 12-17-year-olds, a small increased risk of myocarditis and epilepsy following BNT162b2 vaccination was observed. SARS-CoV-2 infection was associated with increased risks of hospitalization for several outcomes, but these risks were largely absent in vaccinated children. The study concludes a favorable safety profile of COVID-19 vaccination in under-18s.

Publisher

Nature Communications

Published On

May 27, 2024

Authors

Emma Copland, Martina Patone, Defne Saatci, Lahiru Handunnetthi, Jennifer Hirst, David P. J. Hunt, Nicholas L. Mills, Paul Moss, Aziz Sheikh, Carol A. C. Coupland, Anthony Harnden, Chris Robertson, Julia Hippisley-Cox

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